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Weight Loss and Asthma: A Systematic Review (August 2008) |
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Theresa Skybo, an instructor at the Mount Carmel College of Nursing,
co-authored a systematic review of the impact of weight loss on asthma
symptoms. It was published in the August 2008 issue of Thorax.
Eneli, I. U., Skybo T., & Camargo, C. A. (2008).
Weight loss and asthma: a systematic review.
Thorax, 63, 671–676. [PMID: 18663068]
Abstract: Epidemiological studies first demonstrated the association between obesity and
asthma and they have begun to provide additional evidence to support causality: a
dose-effect relationship, consistency across studies (especially among women) and
the correct temporal order (ie, obesity before asthma). To date, relatively few
studies have addressed reversibility, an important but less frequently
demonstrated epidemiological criterion of causality. Reversibility suggests that
if excessive weight is a risk factor for asthma, then reducing body weight should
decrease the prevalence of asthma, or at least decrease asthma related symptoms
or health care utilisation. We performed a systematic review on weight loss and
asthma, based on searches between January 1966 and January 2007 of both PubMed
and the Cochrane Clinical Trial Database. Of the 15 relevant studies, asthma was
the primary outcome in only five. Only one study was conducted in children.
Regardless of the type of intervention (surgical vs medical), all 15 studies
noted an improvement in at least one asthma outcome after weight loss. The
improvement was noted across studies that differed in sample age, gender or
country of origin. The heterogeneity of the interventions and outcomes precluded
quantitative synthesis. We briefly review the role of specific factors (eg,
gastro-oesophageal reflux) in the weight loss-asthma association, and potential
directions for future research.
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